- •Preface to the 3rd edition
- •General Pharmacology
- •Systems Pharmacology
- •Therapy of Selected Diseases
- •Subject Index
- •Abbreviations
- •General Pharmacology
- •History of Pharmacology
- •Drug and Active Principle
- •The Aims of Isolating Active Principles
- •European Plants as Sources of Effective Medicines
- •Drug Development
- •Congeneric Drugs and Name Diversity
- •Oral Dosage Forms
- •Drug Administration by Inhalation
- •Dermatological Agents
- •From Application to Distribution in the Body
- •Potential Targets of Drug Action
- •External Barriers of the Body
- •Blood–Tissue Barriers
- •Membrane Permeation
- •Binding to Plasma Proteins
- •The Liver as an Excretory Organ
- •Biotransformation of Drugs
- •Drug Metabolism by Cytochrome P450
- •The Kidney as an Excretory Organ
- •Presystemic Elimination
- •Drug Concentration in the Body as a Function of Time—First Order (Exponential) Rate Processes
- •Time Course of Drug Concentration in Plasma
- •Time Course of Drug Plasma Levels during Repeated Dosing (A)
- •Time Course of Drug Plasma Levels during Irregular Intake (B)
- •Accumulation: Dose, Dose Interval, and Plasma Level Fluctuation (A)
- •Dose–Response Relationship
- •Concentration–Effect Curves (B)
- •Concentration–Binding Curves
- •Types of Binding Forces
- •Agonists—Antagonists
- •Other Forms of Antagonism
- •Enantioselectivity of Drug Action
- •Receptor Types
- •Undesirable Drug Effects, Side Effects
- •Drug Allergy
- •Cutaneous Reactions
- •Drug Toxicity in Pregnancy and Lactation
- •Pharmacogenetics
- •Placebo (A)
- •Systems Pharmacology
- •Sympathetic Nervous System
- •Structure of the Sympathetic Nervous System
- •Adrenergic Synapse
- •Adrenoceptor Subtypes and Catecholamine Actions
- •Smooth Muscle Effects
- •Cardiostimulation
- •Metabolic Effects
- •Structure–Activity Relationships of Sympathomimetics
- •Indirect Sympathomimetics
- •Types of
- •Antiadrenergics
- •Parasympathetic Nervous System
- •Cholinergic Synapse
- •Parasympathomimetics
- •Parasympatholytics
- •Actions of Nicotine
- •Localization of Nicotinic ACh Receptors
- •Effects of Nicotine on Body Function
- •Aids for Smoking Cessation
- •Consequences of Tobacco Smoking
- •Dopamine
- •Histamine Effects and Their Pharmacological Properties
- •Serotonin
- •Vasodilators—Overview
- •Organic Nitrates
- •Calcium Antagonists
- •ACE Inhibitors
- •Drugs Used to Influence Smooth Muscle Organs
- •Cardiac Drugs
- •Cardiac Glycosides
- •Antiarrhythmic Drugs
- •Iron Compounds
- •Prophylaxis and Therapy of Thromboses
- •Possibilities for Interference (B)
- •Heparin (A)
- •Hirudin and Derivatives (B)
- •Fibrinolytics
- •Intra-arterial Thrombus Formation (A)
- •Formation, Activation, and Aggregation of Platelets (B)
- •Inhibitors of Platelet Aggregation (A)
- •Presystemic Effect of ASA
- •Plasma Volume Expanders
- •Lipid-lowering Agents
- •Diuretics—An Overview
- •NaCl Reabsorption in the Kidney (A)
- •Aquaporins (AQP)
- •Osmotic Diuretics (B)
- •Diuretics of the Sulfonamide Type
- •Potassium-sparing Diuretics (A)
- •Vasopressin and Derivatives (B)
- •Drugs for Gastric and Duodenal Ulcers
- •Laxatives
- •Antidiarrheal Agents
- •Drugs Affecting Motor Function
- •Muscle Relaxants
- •Nondepolarizing Muscle Relaxants
- •Depolarizing Muscle Relaxants
- •Antiparkinsonian Drugs
- •Antiepileptics
- •Pain Mechanisms and Pathways
- •Eicosanoids
- •Antipyretic Analgesics
- •Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
- •Cyclooxygenase (COX) Inhibitors
- •Local Anesthetics
- •Opioid Analgesics—Morphine Type
- •General Anesthesia and General Anesthetic Drugs
- •Inhalational Anesthetics
- •Injectable Anesthetics
- •Sedatives, Hypnotics
- •Benzodiazepines
- •Pharmacokinetics of Benzodiazepines
- •Therapy of Depressive Illness
- •Mania
- •Therapy of Schizophrenia
- •Psychotomimetics (Psychedelics, Hallucinogens)
- •Hypothalamic and Hypophyseal Hormones
- •Thyroid Hormone Therapy
- •Glucocorticoid Therapy
- •Follicular Growth and Ovulation, Estrogen and Progestin Production
- •Oral Contraceptives
- •Antiestrogen and Antiprogestin Active Principles
- •Aromatase Inhibitors
- •Insulin Formulations
- •Treatment of Insulin-dependent Diabetes Mellitus
- •Treatment of Maturity-Onset (Type II) Diabetes Mellitus
- •Oral Antidiabetics
- •Drugs for Maintaining Calcium Homeostasis
- •Drugs for Treating Bacterial Infections
- •Inhibitors of Cell Wall Synthesis
- •Inhibitors of Tetrahydrofolate Synthesis
- •Inhibitors of DNA Function
- •Inhibitors of Protein Synthesis
- •Drugs for Treating Mycobacterial Infections
- •Drugs Used in the Treatment of Fungal Infections
- •Chemotherapy of Viral Infections
- •Drugs for the Treatment of AIDS
- •Drugs for Treating Endoparasitic and Ectoparasitic Infestations
- •Antimalarials
- •Other Tropical Diseases
- •Chemotherapy of Malignant Tumors
- •Targeting of Antineoplastic Drug Action (A)
- •Mechanisms of Resistance to Cytostatics (B)
- •Inhibition of Immune Responses
- •Antidotes and Treatment of Poisonings
- •Therapy of Selected Diseases
- •Hypertension
- •Angina Pectoris
- •Antianginal Drugs
- •Acute Coronary Syndrome— Myocardial Infarction
- •Congestive Heart Failure
- •Hypotension
- •Gout
- •Obesity—Sequelae and Therapeutic Approaches
- •Osteoporosis
- •Rheumatoid Arthritis
- •Migraine
- •Common Cold
- •Bronchial Asthma
- •Emesis
- •Alcohol Abuse
- •Local Treatment of Glaucoma
- •Further Reading
- •Further Reading
- •Picture Credits
- •Drug Indexes
Abbreviations XI
Abbreviations
6-APA |
6-aminopenicillanic acid |
ER |
endoplasmic reticulum |
AA |
amino acid |
FSH |
follicle stimulating hormone |
ABP |
arterial blood pressure |
GABA |
γ-aminobutyric acid |
AC |
adrenal cortex |
GDP |
guanosine diphosphate |
ACE |
angiotensin-converting |
GnRH |
gonadotropin-releasing |
|
enzyme |
|
hormone = gonadorelin: |
ACh |
acetylcholine |
GRH |
growth hormone-releasing |
AChE |
acetylcholinesterase |
|
hormone = somatorelin |
ADH |
antidiuretic hormone |
GRIH |
growth hormone release-in- |
|
(= vasopressin, AVP) |
|
hibiting hormone |
AH |
adenohypophyseal |
|
= somatostatin |
AP |
action potential |
GTP |
guanosine triphosphate |
ATP |
adensosine triphosphate |
HCG |
human chorionic gonadotro- |
AVP |
vasopressin (= antidiuretic |
|
pin |
|
hormone, ADH) |
HIT II |
heparin-induced thrombocy- |
BMI |
Body-Mass-Index |
|
topenia type II |
BP |
blood pressure |
HMG |
human menopausal |
BP |
boiling point |
|
gonadotropin |
CAH |
carbonic anhydrase |
i.m. |
intramuscular(ly) |
cAMP |
cyclic adenosine |
i.v. |
intravenous(ly) |
|
monophosphate |
IFN |
interferon |
CG |
cardiac glycoside |
IFN-α |
interferon alpha |
cGMP |
cyclic guaniidine monophos- |
IFN-β |
interferon beta |
|
phate |
IFN-γ |
interferon gamma |
CHH |
corticotropin-releasing |
IGF-1 |
insulin-like growth factor 1 |
|
hormone |
IL |
interleukins |
CHO |
Chinese hamster ovary |
IOP |
intraocular pressure |
CHT |
specific choline-transporter |
IP3 |
inositol trisphosphate |
CML |
chronic myeloic leukemia |
ISA |
intrinsic sympathomimetic |
CNS |
central nervous system |
|
activity |
COMT |
catecholamine O-methyl |
ISDN |
isosorbide dinitrate |
|
transferase |
ISMN |
5-isosorbide mononitrate |
CRH |
corticotropin-releasing |
LH |
luteinizing hormone |
|
hormone |
M |
moles/liter, mol/l |
DAG |
diacylglycerol |
MAC |
minimal alveolar concentra- |
DHF |
dihydrofolic acid, dihydro- |
|
tion |
|
folate |
MAO |
monoamine oxidase |
DHT |
dihydrotestosterone |
mesna |
sodium 2-mercaptoethane- |
DNA |
deoxyribonucleic acid |
|
sulfonate |
DPTA |
diethylenetriamino- |
MHC |
major histocompatibility |
|
pentaacetic acid |
|
complex |
DRC |
dose–response curves |
MI |
myocardial infarction |
ECL |
enterochromaf n-like |
mM |
millimoles/liter, mmol/l |
EDRF |
endothelium-derived relaxant |
mmHg |
millimeters of mercury |
|
factor |
mRNA |
messenger RNA |
EEG |
electroencephalogram |
mTOR |
mammalian target of |
EFV |
extracellular fluid volume |
|
rapamycin |
EMT |
extraneuronal monoamine |
MW |
molecular weight |
|
transporter |
NAChR |
nicotinic receptor |
Luellmann, Color Atlas of Pharmacology © 2005 Thieme
All rights reserved. Usage subject to terms and conditions of license.
XII |
Abbreviations |
|
|
NAT |
norepinephrine transporter |
SJS |
Steven–Johnson syndrome |
NE |
norepinephrine |
TEN |
toxic epidermal necrolysis |
NFAT |
nuclear factor of activated |
SR |
sarcoplasmic reticulum |
|
T cells |
SSRI |
selective serotonin reuptake |
NH |
neurohypophyseal |
|
inhibitors |
NMDS |
N-methyl-d-asparate |
STEMI |
ST elevation MI |
NSTEMI |
non-STEMI (non-ST |
THF |
tetrahydrofolic acid, |
|
elevation MI) |
|
tetrahydrofolate |
NTG |
nitroglycerin |
TIVA |
total intravenous anaesthesia |
NYHA |
New York Heart Association |
TMPT |
thiopurine methyltransferase |
PABA |
p-aminobenzoic acid |
TNFα |
necrosis factor α |
PAMBA |
p-aminomethylbenzoic acid |
t-PA |
tissue plasminogen activator |
PDE |
phosphodiesterase |
TRH |
thyrotropin-releasing hor- |
PF3 |
platelet factor 3 |
|
mone = protirelin |
PL |
phospholipid |
VAChT |
vesicular ACh transporter |
PLC |
phospholipase C |
VMAT |
vesicular monoamine trans- |
PPARα |
peroxisome proliferator- |
|
porter |
PPARγ |
activated receptor alpha |
|
|
peroxisome proliferator- |
Pharmacokinetic parameters |
||
|
activated receptor gamma |
B |
|
PRIH |
prolactin release inhibiting |
|
|
Bmax |
|
||
|
hormone = dopamine |
|
|
|
c0 |
|
|
REM |
rapid eye movement |
|
|
Cltot |
|
||
rER |
rough endoplasmic reticulum |
cmax |
|
RNA |
ribonucleic acid |
|
|
ct |
|
||
rt-PA |
recombinant tissue plasmino- |
|
|
F |
|
||
RyR |
gen activator |
k |
|
ryanodine receptors |
KD |
|
|
s.c. |
subcutaneous(ly) |
|
|
t½ |
|
||
sER |
smooth endoplasmic reticu- |
Vapp |
|
|
lum |
|
|
SERM |
selective estrogen receptor |
|
|
|
modulators |
|
|
Luellmann, Color Atlas of Pharmacology © 2005 Thieme
All rights reserved. Usage subject to terms and conditions of license.