- •Table of Contents
- •Copyright
- •Contributors
- •How to Use this Study Guide
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
- •Answers
- •4: Outcomes Research
- •Questions
- •Answers
- •5: Core Principles of Perioperative Care
- •Questions
- •Answers
- •Questions
- •Answers
- •7: Principles of Urologic Endoscopy
- •Questions
- •Answers
- •8: Percutaneous Approaches to the Upper Urinary Tract Collecting System
- •Questions
- •Answers
- •Questions
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- •Questions
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- •Questions
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- •12: Infections of the Urinary Tract
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
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- •15: Sexually Transmitted Diseases
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
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- •Questions
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- •Questions
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- •20: Principles of Tissue Engineering
- •Questions
- •Answers
- •Questions
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- •22: Male Reproductive Physiology
- •Questions
- •Answers
- •Questions
- •Answers
- •24: Male Infertility
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
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- •28: Priapism
- •Questions
- •Answers
- •Questions
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- •30: Surgery for Erectile Dysfunction
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
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- •34: Neoplasms of the Testis
- •Questions
- •Answers
- •35: Surgery of Testicular Tumors
- •Questions
- •Answers
- •36: Laparoscopic and Robotic-Assisted Retroperitoneal Lymphadenectomy for Testicular Tumors
- •Questions
- •Answers
- •37: Tumors of the Penis
- •Questions
- •Answers
- •38: Tumors of the Urethra
- •Questions
- •Answers
- •39: Inguinal Node Dissection
- •Questions
- •Answers
- •40: Surgery of the Penis and Urethra
- •Questions
- •Answers
- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •47: Renal Transplantation
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
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- •50: Upper Urinary Tract Trauma
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
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- •53: Strategies for Nonmedical Management of Upper Urinary Tract Calculi
- •Questions
- •Answers
- •54: Surgical Management for Upper Urinary Tract Calculi
- •Questions
- •Answers
- •55: Lower Urinary Tract Calculi
- •Questions
- •Answers
- •56: Benign Renal Tumors
- •Questions
- •Answers
- •57: Malignant Renal Tumors
- •Questions
- •Answers
- •Questions
- •Answers
- •59: Retroperitoneal Tumors
- •Questions
- •Answers
- •60: Open Surgery of the Kidney
- •Questions
- •Answers
- •Questions
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- •62: Nonsurgical Focal Therapy for Renal Tumors
- •Questions
- •Answers
- •Questions
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- •Questions
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- •Questions
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- •66: Surgery of the Adrenal Glands
- •Questions
- •Answers
- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •71: Evaluation and Management of Women with Urinary Incontinence and Pelvic Prolapse
- •Questions
- •Answers
- •72: Evaluation and Management of Men with Urinary Incontinence
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
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- •76: Overactive Bladder
- •Questions
- •Answers
- •77: Underactive Detrusor
- •Questions
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- •78: Nocturia
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
- •Answers
- •Questions
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- •82: Retropubic Suspension Surgery for Incontinence in Women
- •Questions
- •Answers
- •83: Vaginal and Abdominal Reconstructive Surgery for Pelvic Organ Prolapse
- •Questions
- •Answers
- •Questions
- •Answers
- •85: Complications Related to the Use of Mesh and Their Repair
- •Questions
- •Answers
- •86: Injection Therapy for Urinary Incontinence
- •Questions
- •Answers
- •87: Additional Therapies for Storage and Emptying Failure
- •Questions
- •Answers
- •88: Aging and Geriatric Urology
- •Questions
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- •89: Urinary Tract Fistulae
- •Questions
- •Answers
- •Questions
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- •Questions
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- •92: Tumors of the Bladder
- •Questions
- •Answers
- •Questions
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- •Questions
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- •95: Transurethral and Open Surgery for Bladder Cancer
- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •99: Orthotopic Urinary Diversion
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- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •108: Prostate Cancer Tumor Markers
- •Questions
- •Answers
- •Questions
- •110: Pathology of Prostatic Neoplasia
- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •114: Open Radical Prostatectomy
- •Questions
- •Answers
- •Questions
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- •116: Radiation Therapy for Prostate Cancer
- •Questions
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- •117: Focal Therapy for Prostate Cancer
- •Questions
- •Answers
- •Questions
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- •119: Management of Biomedical Recurrence Following Definitive Therapy for Prostate Cancer
- •Questions
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- •120: Hormone Therapy for Prostate Cancer
- •Questions
- •Answers
- •Questions
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- •Questions
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- •Questions
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- •124: Perinatal Urology
- •Questions
- •Answers
- •Questions
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- •126: Pediatric Urogenital Imaging
- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •133: Surgery of the Ureter in Children
- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •137: Vesicoureteral Reflux
- •Questions
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- •138: Bladder Anomalies in Children
- •Questions
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- •139: Exstrophy-Epispadias Complex
- •Questions
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- •140: Prune-Belly Syndrome
- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •144: Management of Defecation Disorders
- •Questions
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- •Questions
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- •Questions
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- •147: Hypospadias
- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •Questions
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- •152: Adolescent and Transitional Urology
- •Questions
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- •Questions
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- •154: Pediatric Genitourinary Trauma
- •Answers
- •Questions
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- •Questions
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e. efflux of Ca.
Answers
1.b. Sympathetic nerves inhibit the bladder body and excite the bladder neck and urethra.
2.e. All are correct.
3.e. All are correct.
4.e. a-c only.
5.a. This is an example of cross-organ sensitization.
6.e. All are correct.
7.e. All are correct.
8.d. b and c are true.
9.e. All are true.
. e. a, c, and d are correct.
. e. All of the above.
. e. a-c are correct.
.a. Switching between bladder storage and emptying can occur involuntarily (reflex emptying) or voluntarily.
. e. a and d are correct.
. e. All of the above.
. e. All of the above.
. d. All of the above.
. a. IP3 hydrolysis and release of intracellular calcium.
. d. All of the above.
. e. a and b are correct.
. e. c and d are correct.
. e. c and d are correct.
. a. Blockade of intracellular vesicle fusion in presynaptic nerves.
. e. c and d are correct.
. d. TLR4
. e. a and b are correct.
. e. c and d are correct.
. e. All are correct.
. e. a and d are correct.
. b. Uroplakins.
. e. All are correct.
. a. Requires energy to maintain, even at rest.
. c. Involves cAMP downstream.
. e. a, b, and d are correct.
. a. Bladder sensation.
. e. a and d are correct.
. d. Urinary urgency with antimuscarinics.
. d. Pdet is not the only measure of bladder's mechanical work ability.
. e. b and d are correct.
. e. a, b, and d are correct.
. d. Inhibition of somatic afferent processing in spinal cord.
. b. Water avoidance stress model.
. e. a, b, and c are correct.
. a. Acetylcholine.
. a. Influx of Na.
Chapter review
1.The bladder has two parts: the body, which lies above the ureteral orifices, and the base, consisting of the trigone and bladder neck.
2.Smooth muscle is able to adjust its length over a much wider range than skeletal muscle. Thus, an empty bladder has a small intravesical space despite the amount of smooth muscle it contains.
3.There is a complete, competent ring of smooth muscle around the bladder neck in the male. This does not occur in the female.
4.In women the density of adrenergic innervation in the bladder neck is less than in men.
5.Myofibroblasts in the lamina propria modulate physiologic interactions between the urothelium and detrusor.
6.Bladder wall blood flow is reduced by distention; in patients with decreased compliance, this effect is pronounced.
7.In the female, the external urethral sphincter covers the ventral surface of the urethra in a horseshoe configuration.
8.The levator ani pelvic floor muscle does not surround the ventral aspect of the urethra in either the male or the female.
9.The external urethral sphincter is composed of (1) periurethral striated muscle of the pelvic floor and (2) striated muscle within the urethra.
10.The bladder urothelium serves a barrier function but is permeable to water to a limited degree and can actively transport sodium.
11.There is no definite evidence that the GAG layer acts as a primary epithelial barrier.
12.Urothelial cells release chemical mediators such as NO, ATP, acetylcholine, and substance P that have excitatory and inhibitory actions on afferent nerves in the bladder wall.
13.Prostaglandins are released from the urothelium.
14.Uroplakin and tight junction proteins are important in maintaining the urothelial barrier function.
15.The normal bladder at rest may be spontaneously active.
16.A low voiding pressure in women does not equate with impaired detrusor contractility.
17.The parasympathetic nerves from S2-4 excite the bladder and relax the urethra. They have afferent fibers. The lumbar sympathetic nerves inhibit the bladder body and excite the bladder base and urethra. They also have afferent fibers. The pudendal nerves (S2-4) excite the external urethral sphincter. Afferent nerve fibers travel with the pudendal nerve as well.
18.There may be parasympathetic afferent and efferent nerve interconnections at the level of the intramural ganglia.
19.Pelvic nerve afferents monitor bladder volume and amplitude of the bladder contraction.
20.The bladder neck and proximal urethra contain the largest density of bladder nerves.
21.Decreased afferent sensitivity or excitability in certain pathologic conditions as well as aging may be an important cause of impaired voiding.
22.Activation of the parasympathetic pathway during voiding triggers the release of NO, which is a major inhibitor of urethral smooth muscle.
23.Cross organization may occur between bladder and bowel, uterus, pelvic urethra, vagina, and prostate. This may contribute to the chronic pelvic pain syndrome.
24.A substantial proportion of the C-fiber afferent population is silent; pathologic conditions may recruit mechanosensitive C-fibers to form a new functional afferent pathway.
25.Activation of the central serotonergic system can suppress voiding by inhibiting the parasympathetic excitatory input to the urinary bladder.
26.The bladder sympathetic reflex promotes closure of the urethral outlet
and inhibits neurally mediated contractions of the bladder.
27.While the bladder fills, the external sphincter activity increases (guarding reflex)—that is, pudendal motor neurons are activated by bladder afferent input.
28.The dorsal pontine tegmentum is the control center for micturition.
29.Stimulation of beta 2 and beta 3 receptors relaxes the detrusor.
30.Sex steroids modulate receptors and influence growth of bladder tissues.
31.After spinal cord injury, a C-fiber–mediated spinal reflex develops and may play a role in the development of detrusor overactivity.
32.Alterations of neural networks occur in the central nervous system following obstruction of the lower urinary tract.
33.Obstruction-induced detrusor overactivity may be due to denervation supersensitivity.
34.With aging detrusor contractility, bladder sensation and urethral pressure decline.
35.Sacral neuromodulation is thought to have its beneficial effect by somatic inhibition of sensory processing in the spinal cord.
36.The hammock hypothesis of urinary continence suggests that the urethra has a fixed dorsal surface due to its attachments to the pubis, pelvic muscles, and fascia, which allows ventral wall compression of the urethra against the fixed dorsal wall.